1.
Immunometabolism at the cornerstone of inflammaging, immunosenescence, and autoimmunity in COVID-19.
Aging (Albany NY)
; 12(24): 26263-26278, 2020 12 27.
Article
in English
| MEDLINE | ID: covidwho-1000742
ABSTRACT
Inflammaging constitutes the common factor for comorbidities predisposing to severe COVID-19. Inflammaging leads to T-cell senescence, and immunosenescence is linked to autoimmune manifestations in COVID-19. As in SLE, metabolic dysregulation occurs in T-cells. Targeting this T-cell dysfunction opens the field for new therapeutic strategies to prevent severe COVID-19. Immunometabolism-mediated approaches such as rapamycin, metformin and dimethyl fumarate, may optimize COVID-19 treatment of the elderly and patients at risk for severe disease.
Subject(s)
Autoimmunity , COVID-19/immunology , COVID-19/metabolism , Energy Metabolism , Host-Pathogen Interactions , Immunosenescence , SARS-CoV-2/immunology , Biomarkers , COVID-19/complications , COVID-19/virology , Cytokine Release Syndrome/etiology , Cytokine Release Syndrome/prevention & control , Enhancer Elements, Genetic , Humans , Promoter Regions, Genetic , SARS-CoV-2/genetics , Signal Transduction , T-Lymphocytes/immunology , T-Lymphocytes/metabolism , TOR Serine-Threonine Kinases/metabolism
2.
Clin Immunol
; 216: 108468, 2020 07.
Article
in English
| MEDLINE | ID: covidwho-350049
Subject(s)
Coronavirus Infections , Pandemics , Pneumonia, Viral , Sepsis , Betacoronavirus , COVID-19 , Humans , SARS-CoV-2 , Ticagrelor
3.
Clin Immunol
; 216: 108464, 2020 07.
Article
in English
| MEDLINE | ID: covidwho-245182